2,5-DiMethyl Celecoxib
- Product Name
- 2,5-DiMethyl Celecoxib
- CAS No.
- 457639-26-8
- Chemical Name
- 2,5-DiMethyl Celecoxib
- Synonyms
- Celecoxib-13;5-dimethyl Celecoxib;Celecoxib Impurity K;Celecoxib impurity T;Celecoxib Impurity 42;Celecoxib 2,5-Dimethyl;2,5-DiMethyl Celecoxib;2,5-DiMethyl-celecoxib DMC;2,5dimethyl Celecoxib,2,5 dimethyl Celecoxib;4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
- CBNumber
- CB92543122
- Molecular Formula
- C18H16F3N3O2S
- Formula Weight
- 395.4
- MOL File
- 457639-26-8.mol
2,5-DiMethyl Celecoxib Property
- Melting point:
- >138°C (dec.)
- Boiling point:
- 516.7±60.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 9.67±0.10(Predicted)
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- D7196
- Product name
- 2,5-Dimethyl-celecoxib
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 35342
- Product name
- 2,5-Dimethyl-celecoxib
- Purity
- VETRANAL , analytical standard
- Packaging
- 10mg
- Price
- $134
- Updated
- 2021/12/16
- Product number
- 10008006
- Product name
- 2,5-dimethyl Celecoxib
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 10008006
- Product name
- 2,5-dimethyl Celecoxib
- Packaging
- 10mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- D7196
- Product name
- 2,5-Dimethyl-celecoxib
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $407
- Updated
- 2024/03/01
2,5-DiMethyl Celecoxib Chemical Properties,Usage,Production
Uses
2,5-Dimethyl-celecoxib has been used
- To block the synthesis of prostaglandin E2 and to study effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression.
- In an in vitro study to analyze its pro-oxidative capacities in metastatic melanoma/ breast cancer cells.
- To study its interaction between silymarin on chemically induced osteoarthritis in rats.
Uses
A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.
Biochem/physiol Actions
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
storage
Room temperature